Since I’m not a commuter (nor have I ever been) I’ve never stayed in a crashpad. That said I do go back to NY every month to see family and the answer (like many questions) is it depends. There are so many factors that can effect the loads on flights, not just holidays. Perfect example I was in NY just this am and wasn’t planning on coming home for 2 more days. Well NY is expecting 2-3’ of snow, the airlines starting cancelling flight and I was forced to leave this am and the flight that had 40 open seats last night had 0 this am (fortunately I was able to get the jumpseat but if there was a more senior pilot I would’ve been out of luck). But wx, yes holidays, school Spring Break, airline sales, destination events all can ruin your day and make a very easy commute into a nightmare.
As Chris said you can go your whole career at one base but that’s really your decision. Some pilots move chasing airplanes or upgrades. As with many things it all depends.